Design, synthesis, and biological evaluation of HDAC6 inhibitors targeting L1 loop and serine 531 residue.  Jha S, Kim JH, Kim M, Nguyen AH, Ali KH, Gupta SK, Park SY, Ha E, Seo YH. Eur J Med Chem. 2024 Feb 5; 265:116057

Exploring new histone deacetylase 6 inhibitors and their effects on reversing the α-tubulin deacetylation and cell morphology changes caused by methamphetamine.Gupta SK, Ali KH, Lee S, Seo YH. Arch Pharm Res. 2023 Oct;46(9-10):795-807

Design, synthesis, and biological evalution of bifunctional inhibitors against Hsp90-HDAC6 interplay. Chae HY, Park SY, Jha S, Gupta SK, Kim M, Ha E, Seo YH. Eur J Med Chem. 2022, 240, 114582.

Rational Design and Synthesis of HSF1-PROTACs for Anticancer Drug Development. Sharma C, Choi MA, Song Y, Seo YH. Molecules. 2022, 27, 1655.

Selective targeting of cancer cells using a hydrogen peroxide-activated Hsp90 inhibitor. Oh YJ, Park SY, Seo YH. Bioorg Chem. 2021, 115, 105195.     

Hybrid inhibitors of DNA and HDACs remarkably enhance cytotoxicity in leukaemia cells. Song Y, Park SY, Wu Z, Liu KH, Seo YH. J Enzyme Inhib Med Chem. 2020, 35(1), 1069-1079

Development of Thiazolidinedione-Based HDAC6 Inhibitors to Overcome Methamphetamine Addiction. Sharma C, Oh YJ, Park B, Lee S, Jeong CH, Lee S, Seo JH, Seo YH. Int J Mol Sci. 2019, 20(24), E6213

Design, synthesis and biological evaluation of a series of CNS penetrant HDAC inhibitors structurally derived from amyloid-β probes. Choi MA, Park SY, Chae HY, Song Y, Sharma C, Seo YH. Sci Rep. 2019, 9(1), 13187

A novel class of anthraquinone-based HDAC6 inhibitors. Song Y, Lim J, Seo YH. Eur J Med Chem. 2019, 164, 263-272

Transcriptome profiling of whisker follicles in methamphetamine self-administered rats. Song SH, Jang WJ, Hwang J, Park B, Jang JH, Seo YH, Yang CH, Lee S, Jeong CH. Sci Rep. 2018, 8(1), 11420

The targeted inhibition of Hsp90 by a synthetic small molecule, DPide offers an effective treatment strategy against TNBCs. Oh YJ, Park SY, Seo YH, Oncol Rep. 2018, 39(4), 1775-1782

Design, synthesis, and biological evaluation of a series of resorcinol-based N-benzyl benzamide derivatives as potent Hsp90 inhibitors. Park SY, Oh YJ, Lho Y, Jeong JH, Liu KH, Song J, Kim SH, Ha E, Seo YH. Eur J Med Chem. 2018, 143, 390-401

Asiatic acid attenuates methamphetamine-induced neuroinflammation and neurotoxicity through blocking of NF-kB/STAT3/ERK and mitochondria-mediated apoptosis pathway. Park JH, Seo YH, Jang JH, Jeong CH, Lee S, Park B, J. Neuroinflammation, 2017, 14(1), 240

Role of hair pigmentation in drug incorporation into hair. Yu H, Jang WJ, Jang JH, Park B, Seo YH, Jeong CH, Lee S. Forensic Sci Int. 2017, 281, 171-175

A novel chalcone-based molecule, BDP inhibits MDA-MB-231 triple-negative breast cancer cell growth by suppressing Hsp90 function. Yong Jin Oh and Young Ho Seo, Oncology reports, 2017, 38(4), 2343-2350

Hsp90 inhibitor SY-016 induces G2/M arrest and apoptosis in paclitaxel-resistant human ovarian cancer cells. Hyun Gyo Lee, Won Jin Park, So Jin Shin, Sang Hoon Kwon, Soon Do Cha, Young Ho Seo, Ju Hui Jeong, Ji Yoon Lee, Chi Heum Cho, Oncol Lett. 2017, 13(4): 2817–2822

YM155 enhances ABT-737-mediated apoptosis through Mcl-1 downregulation in Mcl-1-overexpressed cancer cells. Woo SM, Min KJ, Seo BR, Seo YH, Jeong YJ, Kwon TK. Mol Cell Biochem. 2017, 29(1-2):91-102.

Synthesis and in vitro antiproliferative activity of C5-benzyl substituted 2-amino-pyrrolo[2,3-d]pyrimidines as potent Hsp90 inhibitors. Lee JH, Shin SC, Seo SH, Seo YH, Jeong N, Kim CW, Kim EE, Keum G. Bioorg Med Chem Lett. 2017, 27(2):237-241.

Chalcone-templated Hsp90 inhibitors and their effects on gefitinib resistance in non-small cell lung cancer (NSCLC). Jeong JH, Oh YJ, Kwon TK, Seo YH. Arch Pharm Res. 2017, 40(1):96-105.

Targeting the entry region of Hsp90's ATP binding pocket with a novel 6,7-dihydrothieno[3,2-c]pyridin-5(4H)-yl amide. Jeong JH, Oh YJ, Lho Y, Park SY, Liu KH, Ha E, Seo YH. Eur J Med Chem. 2016, 124, 1069-1080.