Design, synthesis, and biological evaluation of quinazolin-4-one-based selective HDAC6 inhibitors targeting serine 531, histidine 614 residues, and the L1 and L2 loop. Gupta SK, Oh YJ, Kim M, Ha E, Seo YH. Eur J Med Chem. 2025 Dec 15;300:118184

HSP90-specific inhibitor, PSY-2-12, ameliorates cellular senescence via activating autophagy: A potential senotherapeutic target against acute kidney injury. Nhu Nguyen TQ, Nguyen AH, Dao MQ, Kim M, Mai Pham TT, Kim S, Seo JH, Seo YH, Ha E. Biochem Pharmacol. 2025 Dec;242(Pt 2):117336

Design and evaluation of highly selective histone deacetylase 6 inhibitors derived from the natural product tryptoline. Ali KH, Sharma C, Oh YJ, Yu JH, Kim SH, Lee H, Seo YH. Mol Pharmacol. 2025 Aug;107(8):100062

Design, synthesis, and biological evaluation of indazole-based histone deacetylase 6 inhibitors. Ali KH, Gupta SK, Oh YJ, Hossain M, Kim JH, Park SY, Seo YH. Eur J Med Chem. 2025 Oct 5;295:117785

Development of Hsp90 inhibitor to regulate cytokine storms in excessive delayed- and acute inflammation. Sim HB, Sang Son J, Gupta SK, Jeong SH, Choi YJ, Han JY, Ramos SC, Kim H, Park DH, Yoo HJ, Yoo YJ, Chang DJ, Mun SK, Seo YH, Kim JJ. Int Immunopharmacol. 2024 Aug 20;137:112470

Design, synthesis, and biological evaluation of HDAC6 inhibitors targeting L1 loop and serine 531 residue. Jha S, Kim JH, Kim M, Nguyen AH, Ali KH, Gupta SK, Park SY, Ha E, Seo YH. Eur J Med Chem. 2024 Feb 5; 265:116057

SPC-180002, a SIRT1/3 dual inhibitor, impairs mitochondrial function and redox homeostasis and represents an antitumor activity. Cho Y, Hwang JW, Park NJ, Moon J, Ali KH, Seo YH, Kim IS, Kim SN, Kim YK. Free Radic Biol Med. 2023 Nov 1;208:73-87.

Exploring new histone deacetylase 6 inhibitors and their effects on reversing the α-tubulin deacetylation and cell morphology changes caused by methamphetamine.Gupta SK, Ali KH, Lee S, Seo YH. Arch Pharm Res. 2023 Oct;46(9-10):795-807

Design, synthesis, and biological evalution of bifunctional inhibitors against Hsp90-HDAC6 interplay. Chae HY, Park SY, Jha S, Gupta SK, Kim M, Ha E, Seo YH. Eur J Med Chem. 2022, 240, 114582.

Rational Design and Synthesis of HSF1-PROTACs for Anticancer Drug Development. Sharma C, Choi MA, Song Y, Seo YH. Molecules. 2022, 27, 1655.

Selective targeting of cancer cells using a hydrogen peroxide-activated Hsp90 inhibitor. Oh YJ, Park SY, Seo YH. Bioorg Chem. 2021, 115, 105195.     

Hybrid inhibitors of DNA and HDACs remarkably enhance cytotoxicity in leukaemia cells. Song Y, Park SY, Wu Z, Liu KH, Seo YH. J Enzyme Inhib Med Chem. 2020, 35(1), 1069-1079

Development of Thiazolidinedione-Based HDAC6 Inhibitors to Overcome Methamphetamine Addiction. Sharma C, Oh YJ, Park B, Lee S, Jeong CH, Lee S, Seo JH, Seo YH. Int J Mol Sci. 2019, 20(24), E6213

Design, synthesis and biological evaluation of a series of CNS penetrant HDAC inhibitors structurally derived from amyloid-β probes. Choi MA, Park SY, Chae HY, Song Y, Sharma C, Seo YH. Sci Rep. 2019, 9(1), 13187

A novel class of anthraquinone-based HDAC6 inhibitors. Song Y, Lim J, Seo YH. Eur J Med Chem. 2019, 164, 263-272

Transcriptome profiling of whisker follicles in methamphetamine self-administered rats. Song SH, Jang WJ, Hwang J, Park B, Jang JH, Seo YH, Yang CH, Lee S, Jeong CH. Sci Rep. 2018, 8(1), 11420

The targeted inhibition of Hsp90 by a synthetic small molecule, DPide offers an effective treatment strategy against TNBCs. Oh YJ, Park SY, Seo YH, Oncol Rep. 2018, 39(4), 1775-1782

Design, synthesis, and biological evaluation of a series of resorcinol-based N-benzyl benzamide derivatives as potent Hsp90 inhibitors. Park SY, Oh YJ, Lho Y, Jeong JH, Liu KH, Song J, Kim SH, Ha E, Seo YH. Eur J Med Chem. 2018, 143, 390-401

Asiatic acid attenuates methamphetamine-induced neuroinflammation and neurotoxicity through blocking of NF-kB/STAT3/ERK and mitochondria-mediated apoptosis pathway. Park JH, Seo YH, Jang JH, Jeong CH, Lee S, Park B, J. Neuroinflammation, 2017, 14(1), 240

Role of hair pigmentation in drug incorporation into hair. Yu H, Jang WJ, Jang JH, Park B, Seo YH, Jeong CH, Lee S. Forensic Sci Int. 2017, 281, 171-175

A novel chalcone-based molecule, BDP inhibits MDA-MB-231 triple-negative breast cancer cell growth by suppressing Hsp90 function. Yong Jin Oh and Young Ho Seo, Oncology reports, 2017, 38(4), 2343-2350

Hsp90 inhibitor SY-016 induces G2/M arrest and apoptosis in paclitaxel-resistant human ovarian cancer cells. Hyun Gyo Lee, Won Jin Park, So Jin Shin, Sang Hoon Kwon, Soon Do Cha, Young Ho Seo, Ju Hui Jeong, Ji Yoon Lee, Chi Heum Cho, Oncol Lett. 2017, 13(4): 2817–2822

YM155 enhances ABT-737-mediated apoptosis through Mcl-1 downregulation in Mcl-1-overexpressed cancer cells. Woo SM, Min KJ, Seo BR, Seo YH, Jeong YJ, Kwon TK. Mol Cell Biochem. 2017, 29(1-2):91-102.

Synthesis and in vitro antiproliferative activity of C5-benzyl substituted 2-amino-pyrrolo[2,3-d]pyrimidines as potent Hsp90 inhibitors. Lee JH, Shin SC, Seo SH, Seo YH, Jeong N, Kim CW, Kim EE, Keum G. Bioorg Med Chem Lett. 2017, 27(2):237-241.

Chalcone-templated Hsp90 inhibitors and their effects on gefitinib resistance in non-small cell lung cancer (NSCLC). Jeong JH, Oh YJ, Kwon TK, Seo YH. Arch Pharm Res. 2017, 40(1):96-105.

Targeting the entry region of Hsp90's ATP binding pocket with a novel 6,7-dihydrothieno[3,2-c]pyridin-5(4H)-yl amide. Jeong JH, Oh YJ, Lho Y, Park SY, Liu KH, Ha E, Seo YH. Eur J Med Chem. 2016, 124, 1069-1080.

Organelle-specific Hsp90 inhibitors. Seo YH. Arch Pharm Res. 2015, 9, 1582-90.

In Vitro Antifungal Activity and Mode of Action of 2',4'-Dihydroxychalcone against Aspergillus fumigatus. Seo YH, Kim SS, Shin KS. Mycobiology. 2015, 2, 150-6.

Dual Inhibitors Against Topoisomerases and Histone Deacetylases. Seo YH. J Cancer Prev. 2015, 2, 85-91.

Discovery of 2',4'-dimethoxychalcone as a Hsp90 inhibitor and its effect on iressa-resistant non-small cell lung cancer (NSCLC). Seo YH. Arch Pharm Res. 2015, 10, 1783-8.

Small Molecule Inhibitors to Disrupt Protein-protein Interactions of Heat Shock Protein 90 Chaperone Machinery. Seo YH. J Cancer Prev. 2015, 1, 5-11.

Nano-mechanical reinforcement in drug-resistant ovarian cancer cells. Seo YH, Jo YN, Oh YJ, Park S. Biol Pharm Bull. 2015, 3, 389-95.

Jeong CH, Park HB, Jang WJ, Jung SH, Seo YH. “Discovery of hybrid Hsp90 inhibitors and their anti-neoplastic effects against gefitinib-resistant non-small cell lung cancer (NSCLC)” Bioorg Med Chem Lett. 2014, 24, 224-7.

Lee T, Seo YH.” Targeting the hydrophobic region of Hsp90's ATP binding pocket with novel 1,3,5-triazines” Bioorg Med Chem Lett. 2013, 23. 6427-31

Seo, Young Ho “Discovery of Licochalcone A as a Natural Product Inhibitor of Hsp90 and Its Effect on Gefitinib Resistance in Non-Small Cell Lung Cancer (NSCLC)” Bull. Korean Chem. Soc. 2013. 34, 1917

Li Y, Karagöz GE, Seo Young Ho, Zhang T, Jiang Y, Yu Y, Duarte AM, Schwartz SJ, Boelens R, Carroll K, Rüdiger SG, Sun D “Sulforaphane inhibits pancreatic cancer through disrupting Hsp90-p50(Cdc37) complex and direct interactions with amino acids residues of Hsp90.” J Nutr Biochem. 2012, 23, 1617.

Truong, Thu H; Garcia, Francisco J; Seo, Young Ho; Carroll, Kate S. “Isotope-Coded Chemical Reporter and Acid-Cleavable Affinity Reagents for Monitoring Protein Sulfenic Acids” Bioorganic & Medicinal Chemistry letters, 2011, 21, 5015.

Seo, Young Ho; Carroll, Kate S. “Quantification of Protein Sulfenic Acid Modification Using Isotope-Coded Dimedone and Iododimedone (ICDID)” Angewandte Chemie International Edition, (2011), 50, 6, 1342. Accepted as a Very Important Paper (VIP) and Highlighted in ScienceDaily, 2011, 1, 7. 

Seo, Young Ho; Carroll, Kate S. “Profiling Protein Thiol Oxidation in Tumor Cells Using Sulfenic Acid-specific Antibodies.” PNAS, 2009, 106, 16163.

Highlighted in University Michigan News Service, 2009, 9, 7 and commercialized in US market.

Seo, Young Ho; Carroll, Kate S. “Facile Synthesis and Biological Evaluation of a Cell-Permeable Probe to Detect Redox-Regulated Proteins.” Bioorganic & Medicinal Chemistry letters, 2009, 19, 356. 

Reddie, Khalilah G.; Seo, Young Ho; Muse, Wilson B.; Leonard, Stephen E.; Carroll, Kate S. “A chemical approach for detecting sulfenic acid-modified proteins in living cells.” Mol. BioSyst., (2008), 4(6):521-31.

Highlighted in Nature chemical biology, (2008), 4(5), 227 and Highlights in Chemical biology from across RSC Publishing, 2008, 3,14.

Kraus, George A.; Cui, Wenge; Seo, Young Ho “The reaction of aryl triflates and aryl pivalates with electrophiles - The triflate as a meta-directing group.” Tetrahedron Letters (2002), 43(39), 7077-7078.